Lancet Psychiatry 3, 171–178 (2016).ĭepression and Other Common Mental Disorders: Global Health Estimates (World Health Organization, 2017). Estimating the true global burden of mental illness. Our findings provide insight into the genetic architecture of depression and anxiety and comorbidity between them. We use these results to characterize shared and trait-specific genetic associations. Of these associated variants, 72% and 78%, respectively, replicated in an independent cohort of approximately 1.9 million individuals with self-reported diagnosis of depression and anxiety. We used this factor structure to conduct genome-wide association analyses on latent factors of depressive symptoms (89 independent variants, 61 genomic loci) and anxiety symptoms (102 variants, 73 loci) in the UK Biobank. Symptoms of depression and anxiety loaded on two distinct, although highly genetically correlated factors, and neuroticism items were partitioned between them. Here we use factor analysis and genomic structural equation modelling to investigate the genetic factor structure underlying 28 items assessing depression, anxiety and neuroticism, a closely related personality trait. Nature Human Behaviour volume 5, pages 1432–1442 ( 2021) Cite this articleĭepression and anxiety are highly prevalent and comorbid psychiatric traits that cause considerable burden worldwide. Symptom-level modelling unravels the shared genetic architecture of anxiety and depression

Sigmaplot 11 do not test bonferroni